If you're on any previous version - I suggest that you update to the latest multiMAN.
Added: Threaded processing in background for downloading covers (no more GUI interruptions)
Added: XMMB mode will invoke download of missing covers, too
Added: Caching of Retro column
Changed: Non-blockable scanning in XMMB when device is connected/disconnected
Added: Support for Genesis+ GX retro emulator (port by squarepusher2)
Added: Support for FCEUltra (NES/ULTRA) PS3 retro emulator (port by squarepusher2)
Added: Support for VBA PS3 retro emulator (GameBoy/GameBoy Advanced)
Improved: XMMB Photo column display and navigation (no more image buffers release when full - a lot seamless now)
Added: Support for PNG covers for Retro column (408x408 max resolution) (408x180 for best results)
Fixed: Some issues in XMMB mode - all working much more stable now
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It as been at least 6 months since I played my PS3 and I'm not entirely sure what I have missed to allow games to be played. I run the LV2 Patcher v9 before I run Multiman, but games such as Uncharted: Drake's Fortune does not seem to work even though I had luck doing it before. Am I missing something like an update or pkg file that I need to install?