My current PSFreedom build does have options for peek/poke. Looks like it has an option for Blueray Emu w/ peek/poke and Homebrew for peek/poke. I am not forcing patched in Open Manager.
More Info: Ok, I just did a backup from disc of Valkyria Chronicles and it worked fine w/o the disc.
Therefore my PSFreedom build is working fine, and OBM v1.16 is working fine.
So the problem is my backup of Castlevania. Either a corrupt file or some kind of patch problem. I'm not sure what this patch issue could be though, any ideas?