actually, i've done this on a few games. it's possible yes, but you really just have to test it for yourself to see which games you can do it with.
for example, red dead redemption has a file called "rdr2_installed.sdat" which, after RDR is done installing, you can delete it safely.
on the other hand, in fallout 3 GOTY edition, with 6GB of dlc which it installs to take up twice the space, if you delete the dlc from the rip directory, it will reinstall next time you start the game, deleting everything you deleting from the rip directory.
blur has a 1-2gb file that installs, and you can delete it without a problem.
kane and lynch 2 has i think 2-3gb in files that it installs. but if you delete the files after it installs, it will reinstall, deleting everything you deleted from the game directory.
some games just check to see if the content in the install directory is the same as the content to be installed from the disc.
some don't. so you really need to just see for yourself which games you can rip.
also, yes i have tried dummying the installation files to check if it goes by the names but nope, it checks for differences in filesizes too as when i dummied the kane and lynch 2 installation, it reinstalled with my dummied files.