Okay, I've searched for about an hour and I found 20 other problems people have had with backup managers but no one has had this. After I backup a game then try to run it without a disc in the drive, I go to */app_home/PS3_GAME/, I see the game as if it would start.
Then i try and it immediately gives me "An error occurred during the start operation. (80028F14)" I have only tested this with one game because I just jailbroke my PS3 with working Blu-ray drive Uncharted 2, Maybe I need to use an ISO splitter?
I'm using Hermes v4b with iPod Nano 1G rockbox jailbreak, downgraded to 3.41