I thought there was a successful workaround for this problem? Something to do with the "ext game data" setting in multiMAN and maybe some other setting(s). I swear pr0p0sitionJOE posted he was playing it and loving it. So, search around in this thread back several pages for the problem. Good luck!
Found this workaround from another forum: "For those off you out there having a problem with the duplex version of Dishonored installing and then giving you a 'HD Corrupt Data' message after starting a new game there is a fix.
After trying multiple configurations I found the best thing to do is remove all saved data, game data, and data in multiMan in the Hdd0/game directory that has to do with Dishonored (the game data in the game directory might have a different BLESXXXXX name but it has a GD after the title, if your not sure which one it is you can always load an icon.pg picture).
After all game data ect. has been removed, move the GAMES/BLES01674 folder to an external drive (if it is on your internal HD) once there when in multiMAn select the USB version of Dishonored i the list and hit square. Dot the 'Ext Data', 'External', and 'USB Patch' radio buttons, hit circle to go back to the game list and then selected the USB version of dishonored. Once the XMB comes up select the Disc icon and load the game. It may take about 7-10 minutes to install, but once it does there should be no problems.
*If there is no activity after loading the Disc icon and it sits at 0% it means that all the game data has not been removed. You can quit, but I recommend restarting because your installed programs may not be able to load, but worry not, a restart will fix that. Just double check all the dishonored game data again in the XMB and mM.
Forgive me if some one else has posted this somewhere else. I also am in the process of trying to rename and copy the INT Duplex files in to the iSOMNi BLES01675 COOKEDPS3 in the USER DIR folder, will post if that works later when I can test. But for now the version I posted above is working."