1. Fallout
2. Metal Gear Solid
3. Uncharted
4. Pokemon (I still really like the games even though I am not a kid anymore as I am a fan of turn-based rpgs)
5. Disgaea
6. Assassin's Creed (The series is kind of going downhill for me though, as I am very disappointed that they got rid of Jesper Kyd. In addition, Revelations was too easy.)
MOTHER/EarthBound and Paper Mario. Hands freaking down.
I also love Harvest Moon, Pokemon, and a lot of Nintendo classics along with some of the newer Sony stuff (Heavy Rain <3, LBP <3) Assassin's Creed is great but doesn't come close to my two favorites above.