You make a bin/cue image file of the game first then you need a program called PPF-O-MATiC 2.0
which is in the PS2 HDD Navigation
sticky thread and under ps2 utilities and then select ps2homebrew utilities and you then unzip the zip/rar file then open PPF-O-MATiC and in the PPF file window
you put the patch you downloaded for the game manhunt 2, but unzip the patch first from the zip/rar file.
And in the BIN file window
you put the bin image file you made of the game manhunt 2, you don't need the cue file just the bin file, once you have the ppf patch and the bin file in their correct window click on the apply button and that's it your done.
Now just burn that bin image you just patched to a DVD with a burning software that burns bin files like Dvd Decrypter or Imgburn and then enjoy the game on DVD or put onto the PS2 HDD.
Your question should have actually been posted in the PC/TECH Support forum as this is for ps2 hdd related questions, as this is a patching/burning question but will let it slide this time.